Professor Penny Lovat
Professor of Cellular Dermatology and Oncology
- Email: firstname.lastname@example.org
- Telephone: +44 (0) 191 208 7170
- Address: Dermatological Sciences
Institute of Cellular Medicine
The Medical School,
Newcastle upon Tyne,
I am a dermato-oncologist with a focus and specific expertise in cellular signalling in skin biology and cancer, committed to the delivery of high quality translational research, education and teaching. My research emphasis is melanoma and in particular the discovery and translation of novel biomarkers and targeted therapies to improve clinical outcome and the application of this research to postgraduate and undergraduate education.
Roles and Responsibilities
Principle Investigator and Lead of the ICM Dermatological Sciences, Cellular Dermatology and Oncology research group http://www.ncl.ac.uk/icm/research/stratified/dermatology/#overview
Member of the British Skin Foundation (BSF) Grants Advisory Board and lead panel member for the national skin cancer campaign (http://www.ittakesseven.org.uk/).
2008-2015: Member of The British Society for Investigative Dermatology Committee ( http://www.bsid.org.uk/ )
Director of The North Eastern Skin Research Fund (Registered Charity Number: 248634), http://www.nesrf.org.uk/
March 2015- present: Section Editor for The British Journal of Dermatology
Honorary Professor in the Northern Institute for Cancer Research
University Committee Membership
- University Learning and Teaching Review Panel
- Faculty of Medical Sciences Learning, Teaching and Student Experience (FLTSEC) committee
- Faculty of Medical Sciences FLTSEC Taught Regulations and Approval Panel
- Faculty of Medical Sciences FLTSEC Head/Directors of Excellence in Learning and teaching (HELT/DELT) sub committee
- Faculty of Medical Sciences Graduate School Executive Committee
- Institute of Cellular Medicine Executive Board
- Institute of Cellular Medicine Management Board
- Institute of Cellular Medicine Postgraduate Committee
1992: MPhil, University of Newcastle upon Tyne and University of Northumbria
1995 PhD, University of Newcastle upon Tyne and University of Northumbria
2009- July 2015: Senior Lecturer in Cellular Dermatology and Oncology
2007-2009: Lecturer in Cellular Dermatology and Oncology, Newcastle University
2006-2007: Research Council UK Fellow, Newcastle University
2000-2006: Senior Reserach Assocaite, Newcastle University and University of Rome, 'Tor Vergata'
1995-2000: Research Associate, Newcastle University
- International Melanoma Working Group
- The British Association for Cancer Research
- The European Society for Cancer Research
- The British Society for Investigative Dermatology
- The European Society for Dermatological Research
- The European Cell Deah Organisation
- The International Society for Melanoma Research
Translational research in my group is directed towards the molecular and immuno-biology of skin cancer and inflammatory skin disease, with a particular emphasis on the definition and molecular regulation of cellular signalling mechanisms regulating the development and progression of melanoma. A specific focus is the regulation of apoptosis and autophagy and the contribution of these signalling mechanisms to tumour development and therapy resistance, for which we have recently identified a number of novel drug targets as well as prognostic biomarkers able to identify patient subgroups at greatest risk of disease progression.
Research is also focussed towards the development of novel translational models of skin disease, for which drug development and toxicity studies are currently on-going in collaboration with the commercial sector as well the evaluation of potential therapeutics to prevent melanoma invasion and metastasis.
P207153W0 (2014): A novel skin model to study adverse immune reactions and drug sensitivity
UK1419976.4. (2014): Ambra-1 and Loricrin as biomarkers of ulcerative melanoma
Postgraduate Research supervision
I am committed to supporting post graduate research with a proven track record in the successful career development of early/mid career researchers. I have been the primary supervisor to national and international PhD, MD, MRes, and MSc students from both clinical and non-clinical backgrounds, supervising to timely completion 6 PhD, 1MD, 1 MSc, and 10 MRes students since 2009.
I am a Fellow of the Medical Sciences Graduate School and welcome informal enquiries from prospective doctoral or masters students.
Current PhD supervision:
- Dr Stamatina Verykiou, CRUK Doctoral fellow, Newcastle University
- Miss Ashleigh McConnell, MRC studentship, Newcastle University
- Miss Emma Woodward, BBSRC Case studentship, Newcastle University
- Mr Moyassar Basil Al-Shaibani, International PhD student, Newcastle University
- Mr Peter Wu, International PhD student, Newcastle University
- Mr Neil Robinson- BBSRC PhD student, Durham University
Previous Doctoral Supervision:
- 2013: Robert Ellis, MD, BSF Clinical Fellowship, ICM, Newcastle University
- 2013: Isabella Swindenbank, PhD, Pfizer Ltd Case Studentship, ICM, Newcastle University
- 2013: Christopher McKee, PhD, BSF studentship, ICM, Newcastle University
- 2012: Shaun Martin, PhD, CRUK Studentship, NICR/ICM, Newcastle University
- 2010: David Hill, PhD, BSF Studentship, ICM, Newcastle University
- 2010: Nigel Daniels, PhD, ICM, Newcastle University
- 2010: Quan Long, PhD, ICM, Newcastle University
I am the principle investigator of research council, national charity and commercially funded projects, currently including:
- Targeting MEK and VEGF inhibition to prevent uveal and cutaneous melanoma chemo taxis and angiogenesis
- Translating autophagy for melanoma benefit
- Contribution of autophagy to the maintenance, invasion and metastasis of melanoma stem-like populations
- Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death
- TGFB mediated down regulation of Ambra-1 as a surrogate marker for melanoma ulceration
- Targeting TGFB to prevent melanoma ulceration and metastasis
- Harnessing Autophagy for the clinical benefit of oropharyngeal squamous cell carcinoma
- Development of 3D fully humanised skin models for adverse drug reactions: a Knowledge Transfer Partnership between Newcastle University and Alcyomics Ltd
I am also a co investigator of other currently funded melanoma research projects and studies addressing the contribution of deregulated autophagy or apoptosis to other disease settings including:
- Cross-presentation of Melan-A by cutaneous CD141high dendritic cells as a strategy to enhance cytotoxic responses against melanoma
- Cathepsin D mediated induction of autophagy following AhR activation in the skin
- Unveiling the mechanisms by which glucagon-like peptide 1 protects pancreatic beta-cells from programmed cell death
- Cancer Research UK
- The National Council for Replacement, Refinement and Reduction of animals in research
- Innovate UK
- The British Skin Foundation
- The Psoriasis Association
- The Italian Association for Cancer Research
- The Wellcome Trust
- Diabetes UK
- The Newcastle Healthcare Charity
- The Newcastle upon Tyne NHS Foundation Trust
- The JGW Patterson Foundation
- The North Eastern Skin Research Fund
- BBSRC case Phd Studentship with Astra Zeneca Ltd
- MRC/Faculty of Medical Sciences PhD studentship
November 2014: Plenary Presentation, International Society for Melanoma Research, Zurich, Switzerland
May 2014: Invited Plenary Speaker, Melanoma Focus UK, Oxford, UK
April 2014: Local Organiser of The British Society for Investigative Dermatology Annual Meeting (245 delegates)
May 2013: Invited Plenary Speaker to The International Melanoma Working Group (Chair, J Kirkwood, Pittsburgh, USA), Prague, Czechoslovakia
November 2011: Plenary Speaker, International Society for Melanoma Research, Tampa, USA
November 2011: Invited International Speaker, The National Institute of Health/National Cancer Institute Oncology Seminar Programme, Bethesda, USA
2010: Invited Panel Member of The British Skin Foundation Grants Advisory Board
September 2010: Invited External Speaker, The Blizzard Institute, London and The Bart’s Hospitals and Queen Mary University of London
September 2010: Co-organiser and lecturer for The European Society for Dermatological Research (ESDR) 'molecular biology and cell signalling' training course (Vienna, Austria)
June 2009: Invited International Plenary Speaker, European Commission FP7, Marie Curie Workshop, Rome Italy
2009: Elected Committee Member of The British Society for Investigative Dermatology
Reviewer for grant and fellowship proposals for the MRC, CRUK, BSF , Wellcome Trust, BBSRC and the European Commission
Reviewer for leading dermatology/oncology/cell signalling journals including Journal of The National Cancer Institute, Cancer Research, Journal of Investigative Dermatology, Journal of Cell Biology, Science Translational Medicine, Cell Death and Differentiation, Autophagy
BSc (hons) Biomedical Sciences and Pharmacology, MSci Biomedical Sciences and MBBS teaching and assessment :
- CMB3000 Stage 3 Research Projects
- CMB3000 Research Project Supervisor
- B210 Stage 3 Pharmacology project Assessor (oral presentations and dissertations)
- BMS4099 Stage 4 Research project Assessor (oral presentations and dissertations)
- MBBS stage I and II SSC Assessor
Personal Tutor to national and international BSc and MBBS students
Academic lead for MRC mission core training for all faculty MRC funded postgraduate students
MRes/MSc in Medical and Molecular Biosciences teaching and assessment:
- MMB8008 Cell Signalling in Health and Disease Lecturer
- MMB8008 Module Assessor (oral presentations and final exam scripts)
- MEDH099 Reserach project supervisor to both MRes and MBBS/MRes intercalating students
- MEDH099 Project Assessor (oral presentations and dissertations)
- MMS8199 Project supervisor and assessor
Personal Tutor to national and international MRes and MSc students
Internal PhD examiner and Assessor
- Zummo FP, Cullen KS, Honkanen-Scott M, Shaw JAM, Lovat PE, Arden C. Glucagon-like peptide-1 protects pancreatic beta-cells from death by increasing autophagic flux and restoring lysosomal function. Diabetes 2017, (ePub ahead of print).
- Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing. Journal of Cell Biology 2017, ePub ahead of print.
- Hernández-Tiedra S, Fabriàs G, Davila D, Salanueva ÍJ, Casas J, Montes LR, Antón Z, García-Taboada E, Salazar-Roa M, Lorente M, Nylandsted J, Armstrong J, López-Valero I, McKee CS, Serrano-Puebla A, García-López R, González-Martinez J, Abad JL, Hanada K, Boya P, Goñi F, Guzman M, Lovat P, Jäättelä M, Alonso A, Velasco G. Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy 2016, (ePub ahead of print).
- Klinonsky DJ, et, al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd Ed.). Autophagy 2016, 12(1), 1-222.
- Al-Shaibani M, Wang X, Lovat P, Dickinson A. Mesenchymal stem cells promote wound healing via differentiation into epidermal keratinocyte-like cells. In: BSID Annual Meeting 2016. 2016, Dundee, Scotland: Wiley-Blackwell.
- Tang DYL, Ellis RA, Lovat PE. Prognostic impact of autophagy biomarkers for cutaneous melanoma. Frontiers in Oncology 2016, 6, 236.
- Carroll B, Dorsal C, Xie L, Lovat P, Korolchuk V. Targeting the persistent activation of mammalian target of rapamycin in BRAF mutated melanoma as a novel therapeutic strategy. In: BSID Annual Meeting. 2016, Dundee, UK: Wiley-Blackwell Publishing Ltd.
- Korolchuk V, Carroll B, Xie L, Dostal C, Lovat P. Targeting the persistent activation of mTOR in B-RAF and NRas mutated melanoma as a novel therapeutic strategy. In: British Skin Foundation, Skin Deep - 20 Years of Research, 20th Anniversary Conference. 2016, London: Wiley-Blackwell Publishing Ltd.
- Woodward E, Elias M, Ribeiro LR, Lovat P, Reynolds N. TCDD-mediated induction of a chloracne phenotype is associated with aryl hydrocarbon receptor activation, deregulated epidermal differentiation, apoptosis and lysosomal processing. In: BSID Annual Meeting. 2016, Dundee, UK: Wiley-Blackwell Publishing Ltd.
- McConnell AT, Ellis R, Pathy B, Plummer R, Lovat PE, O'Boyle G. The prognostic significance and impact of the CXCR4/CXCR7/CXCL12 axis in primary cutaneous melanoma. British Journal of Dermatology 2016, (ePub ahead of print).
- Hill DS, Robinson NDP, Caley MP, Chen M, O'Toole EA, Armstrong JL, Przyborski S, Lovat PE. A novel fully-humanised 3D skin equivalent to model early melanoma invasion. Molecular Cancer Therapeutics 2015, 14(11), 2665-2673.
- Zummo FP, Cullen KS, Lovat PE, Shaw JA, Arden C. An emerging role for autophagy in the regulation of beta cell survival by glucagon-like peptide-1. In: 51st EASD Annual Meeting. 2015, Stockholm, Sweden: Springer.
- Verykiou S, Hill D, Plummer R, Lovat P. Contribution of autophagy to the survival of melanoma-initiating CD271-positive subpopulations. In: British Society of Investigative Dermatology Annual Meeting 2015. 2015, Southampton, UK: Wiley-Blackwell.
- Al-Shaibani MBH, Wang XN, Lovat PE, Dickinson AM. Deciphering the Role of Mesenchymal Stem Cells Paracrine in Wound Closure Acceleration. In: 41st Annual Meeting of the European Society for Blood and Marrow Transplantation. 2015, Istanbul, Turkey: Nature Publishing Group.
- Armstrong JL, Hill DS, McKee CS, Hernandez-Tiedra S, Lorente M, Lopez-Valero I, Anagnostou ME, Babatunde F, Corazzari M, Redfern CPF, Velasco V, Lovat PE. Exploiting Cannabinoid-Induced Cytotoxic Autophagy to Drive Melanoma Cell Death. Journal of Investigative Dermatology 2015, 135(6), 1629-1637.
- Daignault SM, Hill DS, Beaumont KA, Anfosso A, Lovat PE, Weninger W, Haass NK. G1 phase melanoma cells escape proteasome inhibitor cytotoxicity. In: AACR 106th Annual Meeting 2015. 2015, Philadelphia, PA, USA: American Association for Cancer Research.
- Zummo FP, Cullen KS, Lovat PE, Shaw JA, Arden C. Glucagon-like peptide 1 protects pancreatic beta cells from programmed cell death: a role for autophagy. In: Diabetes UK Professional Conference. 2015, London, UK: Wiley-Blackwell Publishing Ltd.
- Corazzari M, Rapino F, Ciccosanti F, Giglio P, Antonioli M, Conti B, Fimia GM, Lovat PE, Piacentini M. Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma. Cell Death & Differentiation 2015, 22(6), 946–958.
- McConnell A, O'Boyle G, Wright M, Plummer R, Lovat P. Targeting mitogen-activated protein kinase kinase to prevent CXCR4-CXCL12 chemotaxis in cutaneous melanoma. In: Annual Meeting of the British Association of Dermatologists. 2015, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
- Ellis R, Verykiou S, Anagnostou M, Hill D, Carling E, Lovat P. Transforming growth factor-beta mediates loss of epidermal integrity and melanoma ulceration. In: British Society for Investigative Dermatology Annual Meeting 2015. 2015, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL.
- Martin S, Lovat PE, Redfern CPF. Cell-Type Variation in Stress Responses as a Consequence of Manipulating GRP78 Expression in Neuroectodermal Cells. Journal of Cellular Biochemistry 2014, 116(3), 438-449.
- Hill DS, Beaumont KA, Anfosso A, Lovat P, Weninger W, Haass NK. Induction of endoplasmic reticulum stress as a strategy for melanoma therapy. In: Annual Meeting of the Society for Investigative Dermatology. 2014, Albuquerque, New Mexico: Nature Publishing Group.
- Whitaker S, Anagnostou ME, Armstrong J, Ellias M, Husain A, Lovat P, Ellis R. Proautophagic Ambra-1 as biomarker of differentiation in cutaneous squamous carcinoma. In: British Society of Investigative Dermatology Annual Meeting. 2014, Newcastle upon Tyne, UK: John Wiley & Sons Inc.
- Ellis RA, Horswell S, Ness T, Lumsdon J, Tooze SA, Kirkham N, Armstrong JL, Lovat PE. Prognostic Impact of p62 Expression in Cutaneous Malignant Melanoma. Journal of Investigative Dermatology 2014, 134(5), 1476-1478.
- Wright TJ, McKee C, Birch-Machin MA, Ellis R, Armstrong JL, Lovat PE. Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy. Clinical and Experimental Dermatology 2013, 38(4), 421-423.
- Martin S, Lamb HK, Brady C, Lefkove B, Bonner MY, Thompson P, Lovat PE, Arbiser JL, Hawkins AR, Redfern CPF. Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78. British Journal of Cancer 2013, 109(2), 433-443.
- O'Boyle G, Swidenbank I, Marshall H, Barker CE, Armstrong J, White SA, Fricker SP, Plummer R, Wright M, Lovat PE. Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070. British Journal of Cancer 2013, 108(8), 1634-1640.
- McKee CS, Hill DS, Redfern CPF, Armstrong JL, Lovat PE. Oncogenic BRAF signalling increases Mcl-1 expression in cutaneous metastatic melanoma. Experimental Dermatology 2013, 22(11), 767-769.
- Armstrong JL, Martin S, Illingworth NA, Jamieson D, Neilson A, Lovat PE, Redfern CPF, Veal GJ. The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide. Oncology Reports 2012, 27(1), 293-298.
- Armstrong JL, Corazzari M, Martin S, Pagliarini V, Falasca L, Hill DS, Ellis N, Al Sabah S, Redfern CPF, Fimia GM, Piacentini M, Lovat PE. Oncogenic B-RAF Signaling in Melanoma Impairs the Therapeutic Advantage of Autophagy Inhibition. Clinical Cancer Research 2011, 17(8), 2216-2226.
- Armstrong JL, Flockhart R, Veal GJ, Lovat PE, Redfern CPF. Regulation of Endoplasmic Reticulum Stress-induced Cell Death by ATF4 in Neuroectodermal Tumor Cells. Journal of Biological Chemistry 2010, 285(9), 6091-6100.
- Martin S, Hill DS, Paton JC, Paton AW, Birch-Machin MA, Lovat PE, Redfern CPF. Targeting GRP78 to enhance melanoma cell death. Pigment Cell and Melanoma Research 2010, 23(5), 675-682.
- Hiscutt EL, Hill DS, Martin S, Kerr R, Harbottle A, Birch-Machin M, Redfern CPF, Fulda S, Armstrong JL, Lovat PE. Targeting X-Linked Inhibitor of Apoptosis Protein to Increase the Efficacy of Endoplasmic Reticulum Stress-Induced Apoptosis for Melanoma Therapy. Journal of Investigative Dermatology 2010, 130(9), 2250-2258.
- Hill DS, Martin S, Armstrong JL, Flockhart R, Tonison JJ, Simpson DG, Birch-Machin MA, Redfern CPF, Lovat PE. Combining the endoplasmic reticulum stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma. Clinical Cancer Research 2009, 15(4), 1192-1198.
- Flockhart RJ, Armstrong JL, Reynolds NJ, Lovat PE. NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma. British Journal of Cancer 2009, 101(8), 1448-1455.
- Lovat PE, Corazzari M, Armstrong JL, Martin S, Pagliarini V, Hill DS, Brown A, Piacentini M, Birch-Machin MA, Redfern CPF. Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress. Cancer Research 2008, 68(13), 5363-5369.
- Armstrong, J.L., Veal, G.J., Redfern, C.P.F., Lovat, P.E. Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours. Apoptosis 2007, 12(3), 613-622.
- Corazzari, M., Lovat, P.E., Armstrong, J.L., Fimia, G.M., Hill, D.S., Birch-Machin, M.A., Redfern, C.P.F., Piacentini, M. Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: The role of stress proteins ERdj5 and ERp57. British Journal of Cancer 2007, 96(7), 1062-1071.
- Lovat, P.E., Corazzari, M., Di Sano, F., Piacentini, M., Redfern, C.P.F. The role of gangliosides in fenretinide-induced apoptosis of neuroblastoma. Cancer Letters 2005, 228(1-2), 105-110.
- Lovat, P.E., Di Sano, F., Corazzari, M., Fazi, B., Donnorso, R., Pearson, A.D.J., Hall, A.G., Redfern, C.P.F., Piacentini, M. Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. Journal of the National Cancer Institute 2004, 96(17), 1288-1299.
- Lovat, P.E., Oliverio, S, Corazzari, M., Rodolfo, C., Ranalli, M., Goranov, B., Melino, G., Redfern,C.P.F., Piacentini, M. Bak: A Downstream Mediator of Fenretinide-Induced Apoptosis of SH-SY5Y Neuroblastoma Cells. Cancer Research 2003, 63(21), 7310-7313.
- Di Sano F, Fazi B, Citro G, Lovat PE, Cesareni G, Piacentini M. Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. Cancer Research 2003, 63(14), 3860-3865.
- Corazzari, M., Lovat, P.E., Oliverio, S., Pearson, A.D.J., Piacentini, M., Redfern, C.P.F. Growth and DNA Damage-Inducible Transcription Factor 153 Mediates Apoptosis in Response to Fenretinide but Not Synergy between Fenretinide and Chemotherapeutic Drugs in Neuroblastoma. Molecular Pharmacology 2003, 64(6), 1370-1378.
- Lovat, P.E., Ranalli, M., Corazzari, M., Raffaghello, L., Pearson, A.D.J., Ponzoni, M., Piacentini, M., Melino, G., Redfern, C.P.F. Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma. Journal of Cellular Biochemistry 2003, 89(4), 698-708.
- Lovat, P.E., Oliverio, S., Ranalli, M., Corazzari, M., Rodolfo, C., Bernassola, F., Aughton, K., Maccarrone, M., Campbell-Hewson, Q., Pearson, A.D.J., Melino, G., Piacentini, M., Redfern, C.P.F. GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. Cancer Research 2002, 62(18), 5158-5167.