In the recent Research Excellence Framework (REF2014) evaluation of all UK universities, the ICaMB submission in the UOA5 unit of assessment was ranked second for Research Output (first among UK university departments) and 5th in the UK overall.
ICaMB possesses state of the art facilities that include recent investment in next generation DNA sequencing, bioinformatics, proteomics and cell imaging. Much of the research in ICaMB concerns fundamental cellular pathways that underpin our understanding of tumorigenesis.
These include the NF-kB pathway, cell cycle regulation and mitosis, the response of cells to anti-cancer therapies, DNA damage response, telomere biology and stress induced cell signalling pathways. Many components of these pathways are known to play key roles in cancer development and are either existing or future targets for therapy.
Researchers and SpecialismsResearchers and Specialisms
Professor Caroline Austin: topoisomerase; TOP2B; leukaemia; DNA damage; genotoxicity
Dr Ian Cowell: gene regulation, nuclear organization and function and DNA repair
Professor Jonathan Higgins: cell division; kinases; chromatin modifications; histones; human cell biology
Dr Jun-yong Huang: chromosome segregation; spindle assembly checkpoint; cell signalling and cell cycle control
Dr Niall Kenneth: intracellular proteins
Dr Viktor Korolchuk: nutrient sensing; mTOR; autophagy; ageing
Professor David Lydall: telomere function; DNA damage response; genome maintenance; cell cycle; yeast
Dr Laura Maringele: cell division (eukaryote); cell sensing and signalling (eukaryote); cancer cell biology; the ageing cell
Professor Brian Morgan: regulation of oxidative stress response; regulation of cell division; fission fusion yeast genetics
Dr Manolis Papamichos Chronakis: genetic analysis , chromatin, genome stability, DNA damage
Dr Joao Passos: biology of ageing; the ageing cell; cell sensing and signalling
Professor Neil Perkins: NF-kB regulation and function; cancer cell proliferation and survival; eukaryotic cell signalling
Dr Gabriele Saretzki: the ageing cell; cell sensing and signalling (eukaryote)
Professor Matthias Trost: mass spectometry, phagosome biology
Professor Thomas von Zglinicki: cell sensing and signalling (eukaryote); the ageing cell; cancer cell biology
Dr Nick Watkins: eukaryotic ribosomes; snoRNPs; ribosomal RNA modifications; Treacher-Collins syndrome; ribosome biogenesis